Henry Loosemore was born c1607 into a musical West Country family, with two of his brothers also becoming prominent musicians during the early Stuart period. (George became organist of Jesus College, and later Trinity College, Cambridge; John succeeded his father Samuel as an important organ builder.) Nothing is known of Henry's early life, but he must have shown great promise to have been appointed organist of King's College in 1627. He took the Cambridge MusB in 1640 and although services were suspended during the Interegnum, his annual stipend continued to be paid. Following the restoration of the monarchy in 1660, Loosemore spent his final years in the service of King's College where he was succeeded (after his death in 1670) by Thomas Tudway, an important figure in Restoration church music.